Monday, February 11, 2008

Outdated Progesterone Research

It is lamentable that this outdated article shows up with so much frequency. The claim that elevated progesterone leads to increased CCR5 chemokine receptor expression is not borne out by more recent research evidence. The results of SIV research linking progesterone to infection susceptibility have failed to be reproduced in humans, and even if women above the age of 45 are more susceptible to infection, there is little evidence that this female age group is progesterone-dominated. Women consistently present lower HIV viremia than men because of progesterone (pdf), and there is, in fact, ample recent research on progesterone's downregulation of CCR5, as well as CXCR4, receptors.

In addition, if older findings link "progesterone therapy" with elevated CCR5 expression, it is important to consider that progesterone therapy uses artificial progestins which, despite pharmaceutical claims to the contrary, react in many ways differently from the way in which natural progesterone does.

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