Monday, February 11, 2008

Beyond Inhibiting Protease

Physicians will often tell their patients that CD4 count increases are a beneficial consequence of successful HIV viremia suppression. There is considerable evidence, however, that CD4 count improvements are due to an HIV-unrelated effect, the suppression of programmed cell death. The cited study even notes the same effect of protease inhibitors on both the lymphocytes of HIV-positive and of HIV-negative patients.

In conclusion, protease inhibitors appear to decrease CD4+ T-cell ICE expression and apoptosis before they affect Fas-R expression in HIV-infected patients. This action was independent of HIV infection, as similar effects were seen in CD4+ T cells from normal controls. Some of the benefit of protease inhibitors may be related to modification of programmed cell death, which increases CD4+ T-cell number.


sadunkal said...

That's pretty interesting to know.

I like the style of this blog in general. Just brief verifiable statements, as far as I can see.

Dr. B G said...


Very VERY cool blog. Thank you for sharing your info.

Progesterone has been used to control intracranial bleeding with great reductions in morbidity, mortality and brain trauma.

Looks like you are into HIV-virology. I'm surprised that Niacin, vitamin B3, has been implicated in protection against transmission. Cyt P450 effects? Immunology? PUMA-G? Mitochondrial antioxidant? All the above? I'd love to hear your thoughts.


Cytotalker said...

Dr. B G,

Much thanks for your kind comment.

Niacinamide is known to reduce free fatty acids, which are known to be immune suppressive not only in AIDS but also in metabolic syndrome diseases such as diabetes. The resulting poor metabolism of glucose results in cortisol dominance, which may lead to increased chemokine receptor expression, enabling retroviral replication. Niacinamide possibly helps to reverse this process.