Wednesday, February 6, 2008

HAART, Immune Activation, and CD4 Redistribution

A previous post discusses the initial exuberant CD4 boost during the first three months of HAART, which was followed afterward by dwindling and ever diminishing increases. Another study attributes this initial boost to mere redistribution, brought about by resolution of immune activation, of lymphocytes from the lymphoid tissues to the bloodstream.

These data provide evidence suggesting that initial increases in blood CD4+ cell counts on HAART are due to redistribution and that this redistribution is mediated by resolution of the immune activation that had sequestered T cells within lymphoid tissues.

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