Wednesday, February 6, 2008

Corticosteroid Usage and PCP Pneumonia Prognosis

Glucocorticoids augment hippocampal neurotoxicity and AIDS dementia caused by gp120. They also team up with gp120 to induce lymphocyte apoptosis. Consequently, their usage, as prescribed by CDC guidelines, raises concern among researchers. An epidemiological study highly correlates glucocorticoid therapy with a significantly lower prognosis in the treatment of PCP pneumonia.

Among severely ill patients, mortality was 3-fold higher when corticosteroids were given according to CDC guidelines. Our findings suggest that that the utility of adjunctive corticosteroids in severe PCP needs to be revisited.

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