Wednesday, January 23, 2008

Immune Activation and CD4 Depletion

While a previous post discusses T cell exhaustion, according to this study, immune activation is closely linked to CD4 depletion while the link to viremia is indirect.

In summary, our findings support a close linkage between immune activation and CD4 cell depletion in HIV infection and only an indirect relationship of these parameters to the virus rate of replication. Although the destruction-replacement hypothesis has been forcibly advocated, a strong case can be made for alternative, immune activation-centered hypotheses. Further comparative studies of the different host/virus systems would allow a more definitive delineation of cause and effect in HIV disease progression, with implications for the choice of treatment strategies.

This is consistent with the role of immune activation in T cell depletion in non-HIV infection.

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