Tuesday, January 15, 2008

Cortisone Counteracts Cortisol-Induced Cell Death

Not all glucocorticoids are lymphotoxic. Cortisone must convert to cortisol in order for lymphotoxicity to occur and cortisone will counteract cortisol's inducing of apoptosis.



Prednisone, a synthetic oxidized-GC, also suppressed the apoptosis-inducing effect of cortisol in a dose-dependent manner.
There are drawbacks to cortisol-blocking by use of prednisone or cortisone, mainly, the ready conversion of cortisone to lymphotoxic cortisol.

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