Thursday, December 13, 2007

Adiponectin and Lipid Regulation

Adiponectin, a hormone whose deficiency is linked to anti-retroviral treatment lipodystrophy and dyslipidemia, is critical for proper metabolic function.

Earlier studies found that obese individuals and those with type 2 diabetes have reduced adiponectin concentrations, the researchers said. The new study examined the effects of that reduced adiponectin on skeletal muscle.

The researchers first examined children whose parents had type 2 diabetes and those with no family history of the disease. Muscle taken from individuals prone to diabetes was insulin resistant and had lower than normal concentrations of mitochondrial enzymes, suggesting some dysfunction, they found. The level of adiponectin also correlated with the estimated number of mitochondria in the muscle samples.

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